A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.

Rosselli, S., Bruno, M., Raimondo, F.M., Spadaro, V., Varol, M., Koparal, A.T., et al. (2012). Cytotoxic effect of eudesmanolides isolated from flowers of Tanacetum vulgare ssp. siculum. MOLECULES, 17(7), 8186-8195 [10.3390/molecules17078186].

Cytotoxic effect of eudesmanolides isolated from flowers of Tanacetum vulgare ssp. siculum

ROSSELLI, Sergio;BRUNO, Maurizio;RAIMONDO, Francesco Maria;SPADARO, Vivienne;MAGGIO, Antonella Maria
2012

Abstract

A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.
Settore BIO/15 - Biologia Farmaceutica
Settore CHIM/06 - Chimica Organica
https://www.mdpi.com/1420-3049/17/7/8186/htm
Rosselli, S., Bruno, M., Raimondo, F.M., Spadaro, V., Varol, M., Koparal, A.T., et al. (2012). Cytotoxic effect of eudesmanolides isolated from flowers of Tanacetum vulgare ssp. siculum. MOLECULES, 17(7), 8186-8195 [10.3390/molecules17078186].
File in questo prodotto:
File Dimensione Formato  
molecules-17-08186 (2).pdf

accesso aperto

Dimensione 239.84 kB
Formato Adobe PDF
239.84 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/65649
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 46
  • ???jsp.display-item.citation.isi??? 44
social impact