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EnglishPeroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis?
Lindholm, D., Eriksson, O., Mäkelä, J., Belluardo, N., & Korhonen, L. (2012). PGC-1α: a master gene that is hard to master. CELLULAR AND MOLECULAR LIFE SCIENCES, 69(15), 2465-2468 [10.1007/s00018-012-1043-0].
| Data di pubblicazione: | 2012 | |
| Titolo: | PGC-1α: a master gene that is hard to master. | |
| Autori: | ||
| Citazione: | Lindholm, D., Eriksson, O., Mäkelä, J., Belluardo, N., & Korhonen, L. (2012). PGC-1α: a master gene that is hard to master. CELLULAR AND MOLECULAR LIFE SCIENCES, 69(15), 2465-2468 [10.1007/s00018-012-1043-0]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00018-012-1043-0 | |
| Abstract: | Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis? | |
| Settore Scientifico Disciplinare: | Settore BIO/09 - Fisiologia Settore BIO/11 - Biologia Molecolare | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| 2012 cell mol life sci.pdf | Articolo pubblicato | N/A | Open Access Visualizza/Apri |
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