Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis?

Lindholm, D., Eriksson, O., Mäkelä, J., Belluardo, N., Korhonen, L. (2012). PGC-1α: a master gene that is hard to master. CELLULAR AND MOLECULAR LIFE SCIENCES, 69(15), 2465-2468 [10.1007/s00018-012-1043-0].

PGC-1α: a master gene that is hard to master.

BELLUARDO, Natale;
2012-01-01

Abstract

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis?
Settore BIO/09 - Fisiologia
Settore BIO/11 - Biologia Molecolare
Lindholm, D., Eriksson, O., Mäkelä, J., Belluardo, N., Korhonen, L. (2012). PGC-1α: a master gene that is hard to master. CELLULAR AND MOLECULAR LIFE SCIENCES, 69(15), 2465-2468 [10.1007/s00018-012-1043-0].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/65129
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