A prompt diagnosis of Cushing's Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST), late night salivary cortisol (LNSC), and urinary-free cortisol (UFC) are recommended, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).
Ceccato, F., Marcelli, G., Martino, M., Concettoni, C., Brugia, M., Trementino, L., et al. (2019). The diagnostic accuracy of increased late night salivary cortisol for Cushing's syndrome: a real-life prospective study. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 42(3), 327-335 [10.1007/s40618-018-0921-1].
The diagnostic accuracy of increased late night salivary cortisol for Cushing's syndrome: a real-life prospective study
Arnaldi, GUltimo
2019-01-01
Abstract
A prompt diagnosis of Cushing's Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST), late night salivary cortisol (LNSC), and urinary-free cortisol (UFC) are recommended, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).
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