Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
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EnglishThe contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm.
Alafaci, C., Salpietro, F., Iacopino, D., Edvinsson, L., & Tomasello, F. (1991). Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 12(3), 55-58.
| Data di pubblicazione: | 1991 |
| Titolo: | Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm. |
| Autori: | |
| Citazione: | Alafaci, C., Salpietro, F., Iacopino, D., Edvinsson, L., & Tomasello, F. (1991). Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 12(3), 55-58. |
| Rivista: | |
| Abstract: | The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm. |
| Settore Scientifico Disciplinare: | Settore MED/27 - Neurochirurgia |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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