Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm.

Alafaci, C; Salpietro, F; IACOPINO, D; Edvinsson, L; Tomasello, F

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The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm.

Data di pubblicazione:	1991
Titolo:	Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm.
Autori:	Alafaci,C Salpietro,FM IACOPINO, Domenico Edvinsson,L Tomasello F. mostra contributor esterni nascondi contributor esterni
Citazione:	Alafaci, C., Salpietro, F., Iacopino, D., Edvinsson, L., & Tomasello, F. (1991). Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 12(3), 55-58.
Rivista:	ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES
Abstract:	The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm.
Settore Scientifico Disciplinare:	Settore MED/27 - Neurochirurgia
Appare nelle tipologie:	1.01 Articolo in rivista

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http://hdl.handle.net/10447/63833

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