We previously reported that responsiveness to methacholine (Mch) in the absence of deep inspiration (DI) decreased in healthy subjects after a short course of exercise training. We assessed whether a similar beneficial effect of exercise on airway responsiveness could occur in asthmatics. Nine patients (M/F: 3/6; mean age±SD: 24±2 yrs) with mild untreated asthma (FEV1: 100±7.4% pred, FEV1/VC 90±6.5%) underwent a series of single dose Mch bronchoprovocations in the absence of DI in the course of a 10 week training rowing program (6 hours/week of submaximal and maximal exercise), at baseline (week 0) and at weeks 5 and 10. The single dose Mch was established as the dose able to induce at least 15% reduction in IVC, and was administered to each subject at every challenge occasion. Five asthmatics (M/F: 1/4; mean age±SD: 26±3 yrs) with similar baseline lung function (FEV1: 102±7.0% pred, and FEV1/VC: 83±6.0%; p=0.57 and p=0.06, respectively) not participating in the exercise training program, served as controls. In the trained group, the Mch-induced reduction in IVC from baseline was 22±10% at week 0, 13±11% at week 5 (p=0.03), 11±8% at week 10 (p=0.028). The Mch-induced reduction in FEV1 did not change with exercise (p=0.69). The reduction in responsiveness induced by exercise was of the same magnitude of that previously obtained in healthy subjects (50% with respect to pre-training). Conversely, Mch-induced reduction in IVC in controls remained unchanged after 10 weeks (% reduction IVC at baseline: 21±20%; after 10 weeks: 29±14%, p= 0.28). This study indicates that a short course of physical training is capable of reducing airway responsiveness in mild asthmatics.
Scichilone, N., Morici, G., Zangla, D., Arrigo, R., Cardillo, I., Bellia, V., et al. (2012). Effects of exercise training on airway closure in asthmatics. JOURNAL OF APPLIED PHYSIOLOGY, 00.
|Data di pubblicazione:||2012|
|Titolo:||Effects of exercise training on airway closure in asthmatics.|
|Citazione:||Scichilone, N., Morici, G., Zangla, D., Arrigo, R., Cardillo, I., Bellia, V., et al. (2012). Effects of exercise training on airway closure in asthmatics. JOURNAL OF APPLIED PHYSIOLOGY, 00.|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1152/japplphysiol.00529.2012|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie Dell'Apparato Respiratorio|
Settore BIO/09 - Fisiologia
|Appare nelle tipologie:||1.01 Articolo in rivista|