Autoimmune hepatitis (AIH) is a chronic liver disease characterized by clinical features analogue to viral and non-autoimmune liver disorders, but with distinct sero-autoimmunologic properties. The disease results from a network of complex interactions involving genetic predisposition, triggering factors, autoantigens and immunoregulatory system. Diagnosis of AIH relies on positive autoantibodies determination and on liver core biopsy histological appearance. Corticosteroid and immunosuppressive drugs are generally useful in the treatment of disease. However, when inflammation cannot be controlled, progression from chronic hepatitis to cirrhosis is often observed and hepatocellular carcinoma may appear at the end stage. Here we reported a case of a woman, affected with AIH. The patient presented features of chronic liver disease of neither viral nor alcoholic aetiology. Serum evidence of hypertraminasemia, hypergammaglobulinemia and specific autoantibodies were the leading points to final diagnosis, which was validated by liver biopsy. The patient was, finally, successfully treated with steroids.

Mansueto, P., Patti, A.M., Seidita, A., D'Alcamo, A., Adragna, F., Di Stefano, L., et al. (2012). Autoimmune liver disease in a sicilian woman. ACTA MEDICA MEDITERRANEA, 28, 13-18.

Autoimmune liver disease in a sicilian woman.

MANSUETO, Pasquale;PATTI, Angelo Maria;SEIDITA, Aurelio;D'ALCAMO, Alberto;ADRAGNA, Floriana;RINI, Giovam Battista
2012

Abstract

Autoimmune hepatitis (AIH) is a chronic liver disease characterized by clinical features analogue to viral and non-autoimmune liver disorders, but with distinct sero-autoimmunologic properties. The disease results from a network of complex interactions involving genetic predisposition, triggering factors, autoantigens and immunoregulatory system. Diagnosis of AIH relies on positive autoantibodies determination and on liver core biopsy histological appearance. Corticosteroid and immunosuppressive drugs are generally useful in the treatment of disease. However, when inflammation cannot be controlled, progression from chronic hepatitis to cirrhosis is often observed and hepatocellular carcinoma may appear at the end stage. Here we reported a case of a woman, affected with AIH. The patient presented features of chronic liver disease of neither viral nor alcoholic aetiology. Serum evidence of hypertraminasemia, hypergammaglobulinemia and specific autoantibodies were the leading points to final diagnosis, which was validated by liver biopsy. The patient was, finally, successfully treated with steroids.
Settore MED/09 - Medicina Interna
Mansueto, P., Patti, A.M., Seidita, A., D'Alcamo, A., Adragna, F., Di Stefano, L., et al. (2012). Autoimmune liver disease in a sicilian woman. ACTA MEDICA MEDITERRANEA, 28, 13-18.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/63551
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