An innovative two stage liquid–liquid biphasic homogeneous protocol for the asymmetric organocatalytic aldol reaction is proposed, based on the use of the cis-ion-tagged proline 8 dissolved in the liquid film of a multilayered ionic liquid covalently bonded to silica gel 4. The resulting catalytically active material 9 is first soaked with cyclohexanone in the presence of water, resulting in a semi-transparent gel, then the aldehyde is added and the mixture stirred at RT. In the first stage, 4 acts as a catalyst reservoir that delivers 8 to the cyclohexanone phase allowing the reaction to take place homogeneously. In the second stage, cyclohexanone is removed under vacuum and the resulting slurry is extracted with anhydrous diethylether. Now 4 acts as a catalyst sponge, redissolving 8. Product extraction is extremely selective; no trace of catalyst is detected in the product-containing phase, and 9 can be easily reused several times with high cumulative productivity values (up to 523).
|Data di pubblicazione:||2012|
|Titolo:||A Liquid–Liquid Biphasic Homogeneous Organocatalytic Aldol Protocol Based on the Use of a Silica Gel Bound Multilayered Ionic Liquid Phase|
|Citazione:||Montroni, E., Lombardo, M., Quintavalla, A., Trombini, C., Gruttadauria, M., & Giacalone, F. (2012). A Liquid–Liquid Biphasic Homogeneous Organocatalytic Aldol Protocol Based on the Use of a Silica Gel Bound Multilayered Ionic Liquid Phase. CHEMCATCHEM, 4(4), 1000-1006.|
|Digital Object Identifier (DOI):||10.1002/cctc.201200125|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Appare nelle tipologie:||1.01 Articolo in rivista|