Objectives: We compared the outcome of anaemic patients undergoing transcatheter (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic valve stenosis.Methods: Anaemic patients (haemoglobin < 13.0 g/dL in men and < 12.0 g/dL in women) undergoing TAVI and SAVR from the OBSERVANT study were the subjects of this analysis.Results: Preoperative anaemia was an independent predictor of 3-year mortality after either TAVI (HR 1.37, 95% CI 1.12-1.68) and SAVR (HR 1.63, 95% CI 1.37-1.99). Propensity score matching resulted in 302 pairs with similar characteristics. Patients undergoing SAVR had similar 30-d mortality (3.6% versus 3.3%, p = .81) and stroke (1.3% versus 2.0%, p = .53) compared with TAVI. The rates of pacemaker implantation (18.6% versus 3.0%, p < .001), major vascular damage (5.7% versus 0.4%, p <.001) and mild-to-severe paravalvular regurgitation (47.4% versus 9.3%, p < .001) were higher after TAVI, whereas acute kidney injury (50.7% versus 27.9%, p < .001) and blood transfusion (70.0% versus 38.6%, p < .001) were more frequent after SAVR. At 3-year, survival was 74.0% after SAVR and 66.3% after TAVI, respectively (p = .065), and freedom from MACCE was 67.6% after SAVR and 58.7% after TAVI, respectively (p = .049).Conclusions: These results suggest that TAVI is not superior to SAVR in patients with anaemia.

D'Errigo P., Biancari F., Rosato S., Tamburino C., Ranucci M., Santoro G., et al. (2018). Transcatheter aortic valve implantation compared with surgical aortic valve replacement in patients with anaemia. ACTA CARDIOLOGICA, 73(1), 50-59 [10.1080/00015385.2017.1327627].

Transcatheter aortic valve implantation compared with surgical aortic valve replacement in patients with anaemia

Pisano C.
Membro del Collaboration Group
;
Ruvolo G.
Membro del Collaboration Group
;
2018-01-01

Abstract

Objectives: We compared the outcome of anaemic patients undergoing transcatheter (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic valve stenosis.Methods: Anaemic patients (haemoglobin < 13.0 g/dL in men and < 12.0 g/dL in women) undergoing TAVI and SAVR from the OBSERVANT study were the subjects of this analysis.Results: Preoperative anaemia was an independent predictor of 3-year mortality after either TAVI (HR 1.37, 95% CI 1.12-1.68) and SAVR (HR 1.63, 95% CI 1.37-1.99). Propensity score matching resulted in 302 pairs with similar characteristics. Patients undergoing SAVR had similar 30-d mortality (3.6% versus 3.3%, p = .81) and stroke (1.3% versus 2.0%, p = .53) compared with TAVI. The rates of pacemaker implantation (18.6% versus 3.0%, p < .001), major vascular damage (5.7% versus 0.4%, p <.001) and mild-to-severe paravalvular regurgitation (47.4% versus 9.3%, p < .001) were higher after TAVI, whereas acute kidney injury (50.7% versus 27.9%, p < .001) and blood transfusion (70.0% versus 38.6%, p < .001) were more frequent after SAVR. At 3-year, survival was 74.0% after SAVR and 66.3% after TAVI, respectively (p = .065), and freedom from MACCE was 67.6% after SAVR and 58.7% after TAVI, respectively (p = .049).Conclusions: These results suggest that TAVI is not superior to SAVR in patients with anaemia.
2018
D'Errigo P., Biancari F., Rosato S., Tamburino C., Ranucci M., Santoro G., et al. (2018). Transcatheter aortic valve implantation compared with surgical aortic valve replacement in patients with anaemia. ACTA CARDIOLOGICA, 73(1), 50-59 [10.1080/00015385.2017.1327627].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/634390
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