Eicosanoids and aneurysms

In the inflammatory process underlying aneurysm onset and progression, eicosanoidsseem to have an important role. Different hypotheses have been tested to describe thecourse of action.Interestingly, the imbalanced synthesis of cyclooxygenase-derived thromboxane A2and prostacyclins seems to be involved in Marfan syndrome. Neutrophil derivedleukotriene B4 and prostaglandin E2 simultaneously have an important role in smoothmuscle cell viability, inflammatory processes and expansion of aneurysm.The involvement of eicosanoids in aneurysm pathophysiology suggested the effect ofnonsteroidal antinflammatory drugs by reducing both inflammation and proteolysis inaneurysm wall