Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial

CASCIO, A; COLOMBA, C; Antinori, S; Paterson, D; TITONE LANZA DI SCALEA, L

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We conducted an open-label randomized controlled trial to compare the efficacy and safety of clarithromycin (15/mg/kg/day in 2 divided doses for 7 days) with those of azithromycin (10 mg/kg/day in 1 dose for 3 days) in the treatment of children with Mediterranean spotted fever. Until now, there has not been a gold-standard therapy for this rickettsial disease in children. Eighty-seven children were randomized to receive 1 of the 2 drugs. The mean time to defervescence (+/- standard deviation) was 46.2+/-36.4 h in the clarithromycin group and 39.3+/-31.3 h in the azithromycin group. These differences were not statistically significant and both drugs were equally well-tolerated. Clarithromycin and azithromycin could be acceptable therapeutic alternatives to chloramphenicol and tetracyclines for children aged < or =8 years with Mediterranean spotted fever. Azithromycin, because it has a long half-life, offers the advantages of administration in a single daily dose and a shorter duration of therapy, which could increase compliance in children

Data di pubblicazione:	2002
Titolo:	Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial
Autori:	CASCIO, ANTONIO COLOMBA, Claudia Antinori, S Paterson, DL TITONE LANZA DI SCALEA, Lucina mostra contributor esterni nascondi contributor esterni
Citazione:	Cascio, A., Colomba, C., Antinori, S., Paterson, D., & TITONE LANZA DI SCALEA, L. (2002). Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial. CLINICAL INFECTIOUS DISEASES, 34(2), 154-158.
Rivista:	CLINICAL INFECTIOUS DISEASES
Appare nelle tipologie:	1.01 Articolo in rivista

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