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EnglishWe conducted an open-label randomized controlled trial to compare the efficacy and safety of clarithromycin (15/mg/kg/day in 2 divided doses for 7 days) with those of azithromycin (10 mg/kg/day in 1 dose for 3 days) in the treatment of children with Mediterranean spotted fever. Until now, there has not been a gold-standard therapy for this rickettsial disease in children. Eighty-seven children were randomized to receive 1 of the 2 drugs. The mean time to defervescence (+/- standard deviation) was 46.2+/-36.4 h in the clarithromycin group and 39.3+/-31.3 h in the azithromycin group. These differences were not statistically significant and both drugs were equally well-tolerated. Clarithromycin and azithromycin could be acceptable therapeutic alternatives to chloramphenicol and tetracyclines for children aged < or =8 years with Mediterranean spotted fever. Azithromycin, because it has a long half-life, offers the advantages of administration in a single daily dose and a shorter duration of therapy, which could increase compliance in children
Cascio, A., Colomba, C., Antinori, S., Paterson, D., & TITONE LANZA DI SCALEA, L. (2002). Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial. CLINICAL INFECTIOUS DISEASES, 34(2), 154-158.
| Data di pubblicazione: | 2002 | |
| Titolo: | Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial | |
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| Citazione: | Cascio, A., Colomba, C., Antinori, S., Paterson, D., & TITONE LANZA DI SCALEA, L. (2002). Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial. CLINICAL INFECTIOUS DISEASES, 34(2), 154-158. | |
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| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Clarithromycin Versus Azithromycin.pdf | N/A | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/63367
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