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EnglishThe effect of Dexamethasone (DEX) on cell division and macromolecular synthesis was investigated in a line (Mc Coy cells, A 9) of synovial fibroblast-like cells derived from human osteoarthritic joints. DEX markedly reduced the proliferation of Mc Coy cells in a time and dose-dependent manner. The maxiamal inhibition (45 %) was found at 500 nM DEX 24 h after incubation and was accompanied by the appearance of giant macrophage-like cells. After DEX treatment cells showed increased content of DNA, proteins and RNA together with the reduction of [3H]-thymidine incorporation into the TCA-precipitable fraction.
Vento, R., Torregrossa, M., Giuliano, M., G., G., & F., P. (1990). The effects of dexamethasone on human synovial fibroblast-like cells, from ostheoarthritic joints, in culture. LIFE SCIENCES, 47(24), 2199-2205.
| Data di pubblicazione: | 1990 | |
| Titolo: | The effects of dexamethasone on human synovial fibroblast-like cells, from ostheoarthritic joints, in culture | |
| Autori: | ||
| Citazione: | Vento, R., Torregrossa, M., Giuliano, M., G., G., & F., P. (1990). The effects of dexamethasone on human synovial fibroblast-like cells, from ostheoarthritic joints, in culture. LIFE SCIENCES, 47(24), 2199-2205. | |
| Rivista: | ||
| Abstract: | The effect of Dexamethasone (DEX) on cell division and macromolecular synthesis was investigated in a line (Mc Coy cells, A 9) of synovial fibroblast-like cells derived from human osteoarthritic joints. DEX markedly reduced the proliferation of Mc Coy cells in a time and dose-dependent manner. The maxiamal inhibition (45 %) was found at 500 nM DEX 24 h after incubation and was accompanied by the appearance of giant macrophage-like cells. After DEX treatment cells showed increased content of DNA, proteins and RNA together with the reduction of [3H]-thymidine incorporation into the TCA-precipitable fraction. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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