The preparation of -perchloroacyl chlorides, from reaction of the corresponding unfunctionalized acyl halides with chlorine, was efficiently achieved under base-catalysis, using a tetraalkylammonium chloride as catalyst. The process is solvent-free and the procedure is easy, inexpensive, and suitable for scale-up.
Bellesia, F., D'Anna, F., Felluga, F., Frenna, V., Ghelfi, F., Parsons, A.F., et al. (2012). Breakthrough in the alfa-perchlorination of acyl chlorides. SYNTHESIS, 44(44), 605-609 [10.1055/s-0031-1289678].
Breakthrough in the alfa-perchlorination of acyl chlorides
D'ANNA, Francesca;FRENNA, Vincenzo;
2012-01-01
Abstract
The preparation of -perchloroacyl chlorides, from reaction of the corresponding unfunctionalized acyl halides with chlorine, was efficiently achieved under base-catalysis, using a tetraalkylammonium chloride as catalyst. The process is solvent-free and the procedure is easy, inexpensive, and suitable for scale-up.
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