We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
Spreghini, E., Orlando, F., Santinelli, A., Pisa, E., Loretelli, C., Manso, E., et al. (2009). Anidulafungin in combination with amphotericin B against Aspergillus fumigatus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 53(9), 4035-4039 [10.1128/AAC.00659-09].
Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.
MILICI, Maria Eleonora;
2009-01-01
Abstract
We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
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