Brain delivery is one of the major challenges for the neuropharmaceutical industry since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the central nervous system (CNS) because of the existence of a physiological low permeable barrier, the blood–brain barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. Many recent data demonstrate that drugs could be transported successfully into the brain using colloidal systems after i.v. injection by several mechanisms such as endocytosis or P-glycoprotein inhibition. This review summarizes the main brain targeted nanoparticulate carriers such as liposomes, lipid nanoparticles, polymeric nanoparticles, and micelles with great potential in drug delivery into the CNS.

Craparo, E.F., Bondì, M.L., Pitarresi, G., Cavallaro, G. (2011). NANOPARTICULATE SYSTEMS FOR DRUG DELIVERY AND TARGETING TO THE CENTRAL NERVOUS SYSTEM. CNS NEUROSCIENCE & THERAPEUTICS, 17(6), 670-677 [10.1111/j.1755-5949.2010.00199.x].

NANOPARTICULATE SYSTEMS FOR DRUG DELIVERY AND TARGETING TO THE CENTRAL NERVOUS SYSTEM

CRAPARO, Emanuela Fabiola;PITARRESI, Giovanna;CAVALLARO, Gennara
2011-01-01

Abstract

Brain delivery is one of the major challenges for the neuropharmaceutical industry since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the central nervous system (CNS) because of the existence of a physiological low permeable barrier, the blood–brain barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. Many recent data demonstrate that drugs could be transported successfully into the brain using colloidal systems after i.v. injection by several mechanisms such as endocytosis or P-glycoprotein inhibition. This review summarizes the main brain targeted nanoparticulate carriers such as liposomes, lipid nanoparticles, polymeric nanoparticles, and micelles with great potential in drug delivery into the CNS.
2011
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Craparo, E.F., Bondì, M.L., Pitarresi, G., Cavallaro, G. (2011). NANOPARTICULATE SYSTEMS FOR DRUG DELIVERY AND TARGETING TO THE CENTRAL NERVOUS SYSTEM. CNS NEUROSCIENCE & THERAPEUTICS, 17(6), 670-677 [10.1111/j.1755-5949.2010.00199.x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/61235
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