BACKGROUND: Immune perturbation likely affects the development of Kaposi sarcoma (KS) among people infected with the KS-associated herpesvirus (KSHV). We tested whether KSHV-seropositive individuals or cases of classic KS (cKS), which typically originates in the leg, had differing delayed-type hypersensitivity (DTH) in the forearm or leg. METHODS: Mantoux DTH with three antigens (Candida, tetanus, PPD) was performed on the forearm and leg of 15 cKS cases, 14 KSHV-positives without KS, and 15 KSHV-negative controls. The diameters of induration responses were compared by group and body site. RESULTS: Leg DTH was greater than forearm DTH among controls (mean difference 5.6 mm, P¼0.0004), whereas this was not observed in cKS cases ( 2.2 mm, P¼0.32) or KSHV-positives (0.5 mm, P¼0.56). Leg-minus-forearm DTH difference was greater in controls compared with cKS cases (P¼0.004) and KSHV-positives (P¼0.002). Leg-plus-forearm DTH was similar in controls (mean 28.2 mm) and cKS cases (24.5 mm, P¼0.60), but it was reduced in KSHV-positives (11.8 mm, P¼0.02), particularly in the leg (P¼0.004) and marginally in the forearm (P¼0.07). CONCLUSION: KS cases had weaker DTH only in the leg, whereas both body sites appeared weaker in KSHV-positives without KS. Both systemic and regional immune alterations may influence the development of this malignancy.

Valenti, R.M., Amodio, E., Nam, J.M., Preiss, L., Graubard, B.I., Romano, N., et al. (2011). Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls. BRITISH JOURNAL OF CANCER, 104(3), 433-436 [10.1038/sj.bjc.6606088].

Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls

VALENTI, Rosalia Maria;AMODIO, Emanuele;ROMANO, Nino;
2011

Abstract

BACKGROUND: Immune perturbation likely affects the development of Kaposi sarcoma (KS) among people infected with the KS-associated herpesvirus (KSHV). We tested whether KSHV-seropositive individuals or cases of classic KS (cKS), which typically originates in the leg, had differing delayed-type hypersensitivity (DTH) in the forearm or leg. METHODS: Mantoux DTH with three antigens (Candida, tetanus, PPD) was performed on the forearm and leg of 15 cKS cases, 14 KSHV-positives without KS, and 15 KSHV-negative controls. The diameters of induration responses were compared by group and body site. RESULTS: Leg DTH was greater than forearm DTH among controls (mean difference 5.6 mm, P¼0.0004), whereas this was not observed in cKS cases ( 2.2 mm, P¼0.32) or KSHV-positives (0.5 mm, P¼0.56). Leg-minus-forearm DTH difference was greater in controls compared with cKS cases (P¼0.004) and KSHV-positives (P¼0.002). Leg-plus-forearm DTH was similar in controls (mean 28.2 mm) and cKS cases (24.5 mm, P¼0.60), but it was reduced in KSHV-positives (11.8 mm, P¼0.02), particularly in the leg (P¼0.004) and marginally in the forearm (P¼0.07). CONCLUSION: KS cases had weaker DTH only in the leg, whereas both body sites appeared weaker in KSHV-positives without KS. Both systemic and regional immune alterations may influence the development of this malignancy.
Settore MED/42 - Igiene Generale E Applicata
Valenti, R.M., Amodio, E., Nam, J.M., Preiss, L., Graubard, B.I., Romano, N., et al. (2011). Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls. BRITISH JOURNAL OF CANCER, 104(3), 433-436 [10.1038/sj.bjc.6606088].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/60706
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