Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX/46,XX, inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.
Santoro, A., Carbone, P., Caradonna, F., Fabbiano, F., Mirto, S., Caronia, F. (1993). A new pericentric inv(8) in acute nonlymphocytic leukemia. CANCER GENETICS AND CYTOGENETICS, 66(1), 77-78 [10.1016/0165-4608(93)90154-e].
A new pericentric inv(8) in acute nonlymphocytic leukemia
Carbone, P;Caradonna, F;
1993-03-01
Abstract
Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX/46,XX, inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.
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