Aging is a complex process that negatively impacts the development of the different systems and its ability to function. Moreover, the Aging rate in humans is not the same, principally due to genetic heterogeneity and environmental factors. The aging rate is measured as the decline of functional capacity and stress resistance. Therefore, several attempts have been made to analyse the individual age, ( so-called biological age) compared to chronological age. The biomarkers of aging are age-related body function or composition, these markers aim to assess the biological age and predict the onset of age-related diseases and/or residual lifetime. Such biomarkers should help in one hand to characterise the biological age and on the other hand to identify individuals at high risk of developing age-associated diseases or disabilities. Unfortunately, most of the markers under discussion are related to age-related diseases rather than to age, so none of these markers discussed in literature is a true biomarker of aging. Hence, we discuss some disease-related biomarkers useful for a better understanding of aging and the development of new strategies to counteract it, essential for improving the quality of life of the elderly population.

Vasto, S., Scapagnini, G., Bulati, M., Candore, G., Castiglia, L., Colonna-Romano, G., et al. (2010). Biomarkers of aging. FRONTIERS IN BIOSCIENCE, 2(1), 392-402.

Biomarkers of aging

VASTO, Sonya;BULATI, Matteo;CANDORE, Giuseppina;CASTIGLIA, Laura;COLONNA ROMANO, Giuseppina;LIO, Domenico;PELLICANO', Mariavaleria;RIZZO, Claudia Maria;CARUSO, Calogero
2010-01-01

Abstract

Aging is a complex process that negatively impacts the development of the different systems and its ability to function. Moreover, the Aging rate in humans is not the same, principally due to genetic heterogeneity and environmental factors. The aging rate is measured as the decline of functional capacity and stress resistance. Therefore, several attempts have been made to analyse the individual age, ( so-called biological age) compared to chronological age. The biomarkers of aging are age-related body function or composition, these markers aim to assess the biological age and predict the onset of age-related diseases and/or residual lifetime. Such biomarkers should help in one hand to characterise the biological age and on the other hand to identify individuals at high risk of developing age-associated diseases or disabilities. Unfortunately, most of the markers under discussion are related to age-related diseases rather than to age, so none of these markers discussed in literature is a true biomarker of aging. Hence, we discuss some disease-related biomarkers useful for a better understanding of aging and the development of new strategies to counteract it, essential for improving the quality of life of the elderly population.
2010
Settore MED/04 - Patologia Generale
Settore MED/05 - Patologia Clinica
Vasto, S., Scapagnini, G., Bulati, M., Candore, G., Castiglia, L., Colonna-Romano, G., et al. (2010). Biomarkers of aging. FRONTIERS IN BIOSCIENCE, 2(1), 392-402.
File in questo prodotto:
File Dimensione Formato  
Frontiers in bio.pdf

accesso aperto

Dimensione 214.27 kB
Formato Adobe PDF
214.27 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/59547
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 67
  • ???jsp.display-item.citation.isi??? ND
social impact