During embryonic development, stem cells undergo the differentiation process so that they can specialize for different functions within the organism. Complex programs of gene transcription are crucial for this process to happen. Epigenetic modifications and the architecture of chromatin in the nucleus, through the formation of specific regions of active as well as inactive chromatin, allow the coordinated regulation of the genes for each cell fate. In this mini-review, we discuss the current knowledge regarding the regulation of three-dimensional chromatin structure during neuronal differentiation. We also focus on the role the nuclear lamina plays in neurogenesis to ensure the tethering of the chromatin to the nuclear envelope

Martino, S., Carollo, P.S., Barra, V. (2023). A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation [10.3390/genes14051046].

A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation

Martino, Salvatore
Primo
;
Carollo, Pietro Salvatore
Penultimo
;
Barra, Viviana
Ultimo
2023-05-06

Abstract

During embryonic development, stem cells undergo the differentiation process so that they can specialize for different functions within the organism. Complex programs of gene transcription are crucial for this process to happen. Epigenetic modifications and the architecture of chromatin in the nucleus, through the formation of specific regions of active as well as inactive chromatin, allow the coordinated regulation of the genes for each cell fate. In this mini-review, we discuss the current knowledge regarding the regulation of three-dimensional chromatin structure during neuronal differentiation. We also focus on the role the nuclear lamina plays in neurogenesis to ensure the tethering of the chromatin to the nuclear envelope
6-mag-2023
Settore BIO/18 - Genetica
Martino, S., Carollo, P.S., Barra, V. (2023). A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation [10.3390/genes14051046].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/593814
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