Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes.

Thomas D., Gaspar D., Sorushanova A., Milcovich G., Spanoudes K., Mullen A.M., et al. (2016). Scaffold and scaffold-free self-assembled systems in regenerative medicine [10.1002/bit.25869].

Scaffold and scaffold-free self-assembled systems in regenerative medicine

Milcovich G.;
2016-06-01

Abstract

Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes.
1-giu-2016
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Thomas D., Gaspar D., Sorushanova A., Milcovich G., Spanoudes K., Mullen A.M., et al. (2016). Scaffold and scaffold-free self-assembled systems in regenerative medicine [10.1002/bit.25869].
File in questo prodotto:
File Dimensione Formato  
Biotech Bioengineering - 2015 - Thomas - Scaffold and scaffold‐free self‐assembled systems in regenerative medicine.pdf

Solo gestori archvio

Descrizione: Review
Tipologia: Versione Editoriale
Dimensione 3.84 MB
Formato Adobe PDF
3.84 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/591654
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 32
social impact