Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid, the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties comparable or better than the starting material. This study presents the development of an innovative platform for viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aiming to reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution with alternative biomaterials. Catanionic vesicles are proposed as physical crosslinker that can guarantee the formation of a ‘soft’, tunable network, offering a dual-therapeutic approach: on the mechanical relief perspective, as well as on the drug/gene delivery strategy. This research focuses on the fabrication and optimization of colloidal networks, driven by the synergistic interaction among catanionic vesicles and cationic modified cellulose polymers. This study tests the hypothesis that cellulose-like polymers can be arranged into functional matrix, mimicking the mechanical properties of healthy synovial fluids.

Milcovich G., Antunes F.E., Farra R., Grassi G., Grassi M., Asaro F. (2017). Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 102, 796-804 [10.1016/j.ijbiomac.2017.04.079].

Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages

Milcovich G.
Primo
;
2017-09-01

Abstract

Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid, the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties comparable or better than the starting material. This study presents the development of an innovative platform for viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aiming to reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution with alternative biomaterials. Catanionic vesicles are proposed as physical crosslinker that can guarantee the formation of a ‘soft’, tunable network, offering a dual-therapeutic approach: on the mechanical relief perspective, as well as on the drug/gene delivery strategy. This research focuses on the fabrication and optimization of colloidal networks, driven by the synergistic interaction among catanionic vesicles and cationic modified cellulose polymers. This study tests the hypothesis that cellulose-like polymers can be arranged into functional matrix, mimicking the mechanical properties of healthy synovial fluids.
1-set-2017
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Milcovich G., Antunes F.E., Farra R., Grassi G., Grassi M., Asaro F. (2017). Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 102, 796-804 [10.1016/j.ijbiomac.2017.04.079].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/591638
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