Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord-(UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.

Russo E., Caprnda M., Kruzliak P., Conaldi P.G., Borlongan C.V., La Rocca G. (2022). Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications [10.1155/2022/2454168].

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

Russo E.
Primo
;
La Rocca G.
Ultimo
2022-01-06

Abstract

Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord-(UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.
6-gen-2022
Settore BIO/17 - Istologia
Russo E., Caprnda M., Kruzliak P., Conaldi P.G., Borlongan C.V., La Rocca G. (2022). Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications [10.1155/2022/2454168].
File in questo prodotto:
File Dimensione Formato  
Russo et al SCI 2022.pdf

accesso aperto

Descrizione: Manoscritto completo
Tipologia: Versione Editoriale
Dimensione 914.67 kB
Formato Adobe PDF
914.67 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/585090
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact