Background: Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens. Methods: Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months. Results: 112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics. Conclusions: Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost.

Ragusa, F.S., Solimando, L., Mandalà, C., Masnata, R., Ciulla, G., Ciriminna, S., et al. (2023). Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 1-5 [10.1007/s40520-023-02386-y].

Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19

Ragusa, Francesco Saverio;Solimando, Luisa;Masnata, Roberta;Ciulla, Gregorio;Ciriminna, Stefano;La Blasca, Francesco;Mansueto, Pasquale;Veronese, Nicola;Barbagallo, Mario
2023-03-25

Abstract

Background: Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens. Methods: Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months. Results: 112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics. Conclusions: Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost.
25-mar-2023
Settore MED/09 - Medicina Interna
Ragusa, F.S., Solimando, L., Mandalà, C., Masnata, R., Ciulla, G., Ciriminna, S., et al. (2023). Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 1-5 [10.1007/s40520-023-02386-y].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/584897
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