Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other. The former would require considerable simulations and entail burdensome interpretations. From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios.

Curcio, L., D'Orsi, L., Cibella, F., Wagnert-Avraham, L., Nachman, D., De Gaetano, A. (2020). A Simple Cardiovascular Model for the Study of Hemorrhagic Shock. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2020 [10.1155/2020/7936895].

A Simple Cardiovascular Model for the Study of Hemorrhagic Shock

Curcio, Luciano
;
2020-12-28

Abstract

Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other. The former would require considerable simulations and entail burdensome interpretations. From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios.
28-dic-2020
Settore ING-INF/01 - Elettronica
Settore ING-INF/06 - Bioingegneria Elettronica E Informatica
Settore MAT/07 - Fisica Matematica
Curcio, L., D'Orsi, L., Cibella, F., Wagnert-Avraham, L., Nachman, D., De Gaetano, A. (2020). A Simple Cardiovascular Model for the Study of Hemorrhagic Shock. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2020 [10.1155/2020/7936895].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/584046
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