The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between the microbiota and the immune system, triggering inflammation and potentially contributing to the pathogenesis and development of chronic inflammatory diseases. This review will summarize the current evidence about the microbiome-immunity cross-talk, especially focusing on the microbiota alterations described in patients with rheumatic diseases and on the recent findings concerning the interaction between microbiota, metabolic function, and the immune system.

La Barbera, L., Macaluso, F., Fasano, S., Grasso, G., Ciccia, F., Guggino, G. (2022). Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(12) [10.3390/ijms23126532].

Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation

La Barbera, Lidia
Primo
Membro del Collaboration Group
;
Macaluso, Federica
Membro del Collaboration Group
;
Fasano, Serena
Membro del Collaboration Group
;
Grasso, Giulia
Membro del Collaboration Group
;
Ciccia, Francesco
Membro del Collaboration Group
;
Guggino, Giuliana
Ultimo
Membro del Collaboration Group
2022-06-10

Abstract

The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between the microbiota and the immune system, triggering inflammation and potentially contributing to the pathogenesis and development of chronic inflammatory diseases. This review will summarize the current evidence about the microbiome-immunity cross-talk, especially focusing on the microbiota alterations described in patients with rheumatic diseases and on the recent findings concerning the interaction between microbiota, metabolic function, and the immune system.
10-giu-2022
La Barbera, L., Macaluso, F., Fasano, S., Grasso, G., Ciccia, F., Guggino, G. (2022). Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(12) [10.3390/ijms23126532].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/582532
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