Recently, the synaptic proteins neurogranin (Ng) and alpha-synuclein (alpha-Syn) have attracted scientific interest as potential biomarkers for synaptic dysfunction in neurodegenerative diseases. In this study, we measured the CSF Ng and alpha-Syn concentrations in patients affected by AD (n = 69), non-AD neurodegenerative disorders (n-AD = 50) and non-degenerative disorders (n-ND, n = 98). The concentrations of CSF Ng and alpha-Syn were significantly higher in AD than in n-AD and n-ND. Moreover, the A beta 42/Ng and A beta 42/alpha-Syn ratios showed statistically significant differences between groups and discriminated AD patients from n-AD patients, better than Ng or alpha-Syn alone. Regression analyses showed an association of higher Ng concentrations with MMSE < 24, pathological A beta 42/40 ratios, pTau, tTau and the ApoE epsilon 4 genotype. A beta 42/Ng was associated with MMSE < 24, an AD-related FDG-PET pattern, the ApoE epsilon 4 genotype, pathological A beta 42 levels and A beta 42/40 ratios, pTau, and tTau. Moreover, APO-E epsilon 4 carriers showed higher Ng concentrations than non-carriers. Our results support the idea that the A beta 42/Ng ratio is a reliable index of synaptic dysfunction/degeneration able to discriminate AD from other neurological conditions.

Piccoli, T., Blandino, V., Maniscalco, L., Matranga, D., Graziano, F., Guajana, F., et al. (2022). Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18) [10.3390/ijms231810831].

Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders

Piccoli, Tommaso;Blandino, Valeria;Maniscalco, Laura;Matranga, Domenica;Graziano, Fabiola;Guajana, Fabrizio;Agnello, Luisa;Lo Sasso, Bruna;Gambino, Caterina Maria;Giglio, Rosaria Vincenza;La Bella, Vincenzo;Ciaccio, Marcello
;
Colletti, Tiziana
2022-09-16

Abstract

Recently, the synaptic proteins neurogranin (Ng) and alpha-synuclein (alpha-Syn) have attracted scientific interest as potential biomarkers for synaptic dysfunction in neurodegenerative diseases. In this study, we measured the CSF Ng and alpha-Syn concentrations in patients affected by AD (n = 69), non-AD neurodegenerative disorders (n-AD = 50) and non-degenerative disorders (n-ND, n = 98). The concentrations of CSF Ng and alpha-Syn were significantly higher in AD than in n-AD and n-ND. Moreover, the A beta 42/Ng and A beta 42/alpha-Syn ratios showed statistically significant differences between groups and discriminated AD patients from n-AD patients, better than Ng or alpha-Syn alone. Regression analyses showed an association of higher Ng concentrations with MMSE < 24, pathological A beta 42/40 ratios, pTau, tTau and the ApoE epsilon 4 genotype. A beta 42/Ng was associated with MMSE < 24, an AD-related FDG-PET pattern, the ApoE epsilon 4 genotype, pathological A beta 42 levels and A beta 42/40 ratios, pTau, and tTau. Moreover, APO-E epsilon 4 carriers showed higher Ng concentrations than non-carriers. Our results support the idea that the A beta 42/Ng ratio is a reliable index of synaptic dysfunction/degeneration able to discriminate AD from other neurological conditions.
Settore MED/26 - Neurologia
Settore MED/01 - Statistica Medica
Piccoli, T., Blandino, V., Maniscalco, L., Matranga, D., Graziano, F., Guajana, F., et al. (2022). Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18) [10.3390/ijms231810831].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/578408
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