A coating technology based on low molecular weight hyaluronic acid (HA) and ferulic acid (FA) was applied to the coating of low generation poly(propylene imine) dendrimers through a biocompatible hexa(ethylene glycol) spacer. The ensuing HA-FA-HEG-PPID dendrimeric materials showed interesting loading capability (between 7.65% and 9.08%) regarding anticancer agent doxorubicin, and their interactions with the drug appeared to hamper the drug release in the physiological environment. Thus, the stable nanostructured loaded delivery systems were able to internalize into cells expressing the HA receptor CD44 and to demonstrate high cytotoxicity comparable to that shown by equivalent amounts of free doxorubicin. Thus, HA-FA-HEG-PPID dendrimeric materials were proposed as biocompatible drug carriers capable of transporting anticancer doxorubicin to tumor cells.

Paolino, M., Varvara, P., Saletti, M., Reale, A., Gentile, M., Paccagnini, E., et al. (2023). Hyaluronan-coated poly(propylene imine) dendrimers as biomimetic nanocarriers of doxorubicin. JOURNAL OF APPLIED POLYMER SCIENCE, 140(2) [10.1002/app.53300].

Hyaluronan-coated poly(propylene imine) dendrimers as biomimetic nanocarriers of doxorubicin

Licciardi, M;
2023-01-01

Abstract

A coating technology based on low molecular weight hyaluronic acid (HA) and ferulic acid (FA) was applied to the coating of low generation poly(propylene imine) dendrimers through a biocompatible hexa(ethylene glycol) spacer. The ensuing HA-FA-HEG-PPID dendrimeric materials showed interesting loading capability (between 7.65% and 9.08%) regarding anticancer agent doxorubicin, and their interactions with the drug appeared to hamper the drug release in the physiological environment. Thus, the stable nanostructured loaded delivery systems were able to internalize into cells expressing the HA receptor CD44 and to demonstrate high cytotoxicity comparable to that shown by equivalent amounts of free doxorubicin. Thus, HA-FA-HEG-PPID dendrimeric materials were proposed as biocompatible drug carriers capable of transporting anticancer doxorubicin to tumor cells.
Paolino, M., Varvara, P., Saletti, M., Reale, A., Gentile, M., Paccagnini, E., et al. (2023). Hyaluronan-coated poly(propylene imine) dendrimers as biomimetic nanocarriers of doxorubicin. JOURNAL OF APPLIED POLYMER SCIENCE, 140(2) [10.1002/app.53300].
File in questo prodotto:
File Dimensione Formato  
J Applied Polymer Sci - 2023 - Paolino.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 4.69 MB
Formato Adobe PDF
4.69 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/578239
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact