Natural killer (NK) cells play a role in defence against viral infections by killing infected cells or by producing cytokines and interacting with adaptive immune cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation of NK cells through their interaction with human leucocyte antigens (HLA). Ninety-six Sicilian patients positive to Human Immunodeficiency Virus-1 (HIV) and ninety-two Sicilian patients positive to SARS-CoV-2 were genotyped for KIRs and their HLA ligands. We also included fifty-six Sicilian patients with chronic hepatitis B (CHB) already recruited in our previous study. The aim of this study was to compare the distribution of KIR-HLA genes/groups of these three different infected populations with healthy Sicilian donors from the literature. We showed that the inhibitory KIR3DL1 gene and the KIR3DL1/HLA-B Bw4 pairing were more prevalent in individual CHB. At the same time, the frequency of HLA-C2 was increased in CHB compared to other groups. In contrast, the HLA-C1 ligand seems to have no contribution to CHB progression whereas it was significantly higher in COVID-19 and HIV-positive than healthy controls. These results suggest that specific KIR-HLA combinations can predict the outcome/susceptibility of these viral infections and allows to plan successful customized therapeutic strategies.

Ligotti, M.E., Aiello, A., Accardi, G., Calabrò, A., Ciaccio, M., Colomba, C., et al. (2022). Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(24), 1-12 [10.3390/ijms232415466].

Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population

Ligotti, Mattia Emanuela;Aiello, Anna;Accardi, Giulia
;
Ciaccio, Marcello;Colomba, Claudia;Di Bona, Danilo;Lo Sasso, Bruna;Pojero, Fanny;Tuttolomondo, Antonino;Caruso, Calogero;Candore, Giuseppina;Duro, Giovanni
2022-12-07

Abstract

Natural killer (NK) cells play a role in defence against viral infections by killing infected cells or by producing cytokines and interacting with adaptive immune cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation of NK cells through their interaction with human leucocyte antigens (HLA). Ninety-six Sicilian patients positive to Human Immunodeficiency Virus-1 (HIV) and ninety-two Sicilian patients positive to SARS-CoV-2 were genotyped for KIRs and their HLA ligands. We also included fifty-six Sicilian patients with chronic hepatitis B (CHB) already recruited in our previous study. The aim of this study was to compare the distribution of KIR-HLA genes/groups of these three different infected populations with healthy Sicilian donors from the literature. We showed that the inhibitory KIR3DL1 gene and the KIR3DL1/HLA-B Bw4 pairing were more prevalent in individual CHB. At the same time, the frequency of HLA-C2 was increased in CHB compared to other groups. In contrast, the HLA-C1 ligand seems to have no contribution to CHB progression whereas it was significantly higher in COVID-19 and HIV-positive than healthy controls. These results suggest that specific KIR-HLA combinations can predict the outcome/susceptibility of these viral infections and allows to plan successful customized therapeutic strategies.
Settore MED/04 - Patologia Generale
https://www.mdpi.com/1422-0067/23/24/15466
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779783/
Ligotti, M.E., Aiello, A., Accardi, G., Calabrò, A., Ciaccio, M., Colomba, C., et al. (2022). Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(24), 1-12 [10.3390/ijms232415466].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/577748
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