Bacillus Calmette-Guerin (BCG) is a vaccine against tuberculosis and contains a live, attenuated strain of Mycobacterium bovis as its essential constituent. Being a live, attenuated strain with potential pathogenicity, BCG can cause different complications, both near the inoculation site and through blood dissemination, especially in patients with immunodeficiency. IFN-gamma R1 deficiency is an autosomal recessively inherited immunodeficiency characterized by predisposition to infections with intracellular pathogens, in particular mycobacteria. We report a rare case of chronic osteomyelitis lasting 30 years due to BCG in a woman with IFN-gamma R1 deficiency who had previous clinical history of multi-organ BCGitis. Diagnosis of chronic osteomyelitis was confirmed by an 18-fluorine fluorodeoxyglucose positron emission tomography combined with CT scan (18F-FDG PET/CT). In children with a history of BCG vaccination and chronic unexplained infections, a clinical suspicion of BCG-related disease must arise, and a reason of immunodeficiency should be sought.

Colomba, C., Rubino, R., Tolomeo, M., Lo Porto, D., Bonura, S., Agrenzano, S., et al. (2022). A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 16(2), 383-387 [10.3855/jidc.15388].

A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland

Colomba, Claudia
Primo
;
Rubino, Raffaella
;
Lo Porto, Davide;Bonura, Silvia;Agrenzano, Stefano;Cascio, Antonio
Ultimo
2022-02-28

Abstract

Bacillus Calmette-Guerin (BCG) is a vaccine against tuberculosis and contains a live, attenuated strain of Mycobacterium bovis as its essential constituent. Being a live, attenuated strain with potential pathogenicity, BCG can cause different complications, both near the inoculation site and through blood dissemination, especially in patients with immunodeficiency. IFN-gamma R1 deficiency is an autosomal recessively inherited immunodeficiency characterized by predisposition to infections with intracellular pathogens, in particular mycobacteria. We report a rare case of chronic osteomyelitis lasting 30 years due to BCG in a woman with IFN-gamma R1 deficiency who had previous clinical history of multi-organ BCGitis. Diagnosis of chronic osteomyelitis was confirmed by an 18-fluorine fluorodeoxyglucose positron emission tomography combined with CT scan (18F-FDG PET/CT). In children with a history of BCG vaccination and chronic unexplained infections, a clinical suspicion of BCG-related disease must arise, and a reason of immunodeficiency should be sought.
Colomba, C., Rubino, R., Tolomeo, M., Lo Porto, D., Bonura, S., Agrenzano, S., et al. (2022). A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 16(2), 383-387 [10.3855/jidc.15388].
File in questo prodotto:
File Dimensione Formato  
A case of disseminated BCG infection in a daughter of Italian immigrants.pdf

accesso aperto

Tipologia: Versione Editoriale
Dimensione 566.19 kB
Formato Adobe PDF
566.19 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/574609
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact