Background The ongoing Coronavirus Disease 2019 (COVID-19) epidemic represents an unprecedented global health challenge. Many COVID-19 symptoms are similar to symptoms that can occur in other infections. Malaria should always be considered in patients with SARS-CoV-2 infection returning from endemic areas. Case presentation We present the first case of multisystem inflammatory syndrome (MIS-C) and Plasmodium vivax-falciparum and SARS-CoV2 coinfection in children. Despite clearance of parassitaemia and a negative COVID-19 nasopharyngeal PCR, the patient's clinical conditions worsened. The World Health Organization (WHO) criteria were used to make the diagnosis of MIS-C. Treatment with intravenous immunoglobulins and methylprednisolone was effective. Conclusions This case emphasizes the importance of considering malaria diagnosis in patients returning from endemic areas, even in the COVID 19 era. Malaria and SARS-CoV2 co-infection may increase the risk of MIS-C, for which early detection is critical for proper management.

Scalisi, M., Giordano, S., Canduscio, L.A., Failla, M.C., Messina, L., Sferrazza, E., et al. (2022). MIS-C and co-infection with P. vivax and P. falciparum in a child: a clinical conundrum. THE ITALIAN JOURNAL OF PEDIATRICS, 48(1) [10.1186/s13052-022-01311-9].

MIS-C and co-infection with P. vivax and P. falciparum in a child: a clinical conundrum

Scalisi, Michela
Primo
;
Canduscio, Laura Antonella;Sferrazza, Elisa;Rubino, Raffaella;Siracusa, Lucia;Vanella, Veronica;Cascio, Antonio;Colomba, Claudia
Ultimo
2022-07-27

Abstract

Background The ongoing Coronavirus Disease 2019 (COVID-19) epidemic represents an unprecedented global health challenge. Many COVID-19 symptoms are similar to symptoms that can occur in other infections. Malaria should always be considered in patients with SARS-CoV-2 infection returning from endemic areas. Case presentation We present the first case of multisystem inflammatory syndrome (MIS-C) and Plasmodium vivax-falciparum and SARS-CoV2 coinfection in children. Despite clearance of parassitaemia and a negative COVID-19 nasopharyngeal PCR, the patient's clinical conditions worsened. The World Health Organization (WHO) criteria were used to make the diagnosis of MIS-C. Treatment with intravenous immunoglobulins and methylprednisolone was effective. Conclusions This case emphasizes the importance of considering malaria diagnosis in patients returning from endemic areas, even in the COVID 19 era. Malaria and SARS-CoV2 co-infection may increase the risk of MIS-C, for which early detection is critical for proper management.
27-lug-2022
Scalisi, M., Giordano, S., Canduscio, L.A., Failla, M.C., Messina, L., Sferrazza, E., et al. (2022). MIS-C and co-infection with P. vivax and P. falciparum in a child: a clinical conundrum. THE ITALIAN JOURNAL OF PEDIATRICS, 48(1) [10.1186/s13052-022-01311-9].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/574606
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