Nutritional supplementation with myo-inositol-D-chiro-inositol: effect on reproductive system functionality in Long-term Survivors of Lymphoma

Introduction/Background: The principal International scientific societies of oncology recommend that Long-term Survivors of Lymphoma join fertility programs. Therefore, we conducted a prospective observational controlled study, with the aim to assess the effects of oral supplementation with Myo-Inositol and D-Chiro-Inositol (MIC) on ovarian function parameters in Long-term Survivors of Lymphoma Methodology: Between January 2020 and January 2021, 90 female patients, long-term Survivors of Lymphoma with an average age of 34 years (range 25-44), were considered eligible and enrolled in the study (Figure 1). The study was registered on ClinicalTrials.gov (ID: NCT05410314). We conducted this study on two groups: the first one (A group) underwent oral supplementation with MIC for 12 months, and the second group (B group) underwent follow-up without any nutritional supplement for 12 months. Statistical analysis: The level of statistical significance was set at p ≤ 0.05. Analysis was conducted with STATA/SE 15.0. Results: In group A a significant reduction after 12 months was observed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), oligomenorrhea and a reduction to the limits of statistical significance for the progesterone (PG) (Table 1). Conclusion: In our data analysis, comparing ovarian function parameters in group A women between baseline (T0) and after 12 months of oral supplementation with MIC, a significant reduction in FSH and an increase in PG and antral follicle count (AFC) of the right ovary resulted. This result could be due, at least in part, to the known MIC effect on ovulation improvement that contrasts with luteal insufficiency, typical in these patients. The limitations of our study should also be considered, such as the lack of previous similar studies, thus not allowing a direct comparison with other clinical experiences, and the low number of enrolled women. Therefore, further studies are needed to confirm our preliminary findings in a larger setting.