The aim of this Perspective is to start a discussion about the real usefulness of more or less sophisticated catalytic systems for the Knoevenagel reaction with malononitrile, a reaction that can take place under mild conditions without the need of a catalyst. From a sustainable viewpoint the questions are: Is it useful to increase the rate of a reaction that already occurs under mild conditions? Is it useful to spend resources and time in designing, characterizing and realizing complex catalytic systems for such reaction? Does it make sense to carry out the reaction under conditions such as to have a slower reaction rate and therefore to find a catalyst that is able to increase it?

Campisciano V., Giacalone F., Gruttadauria M. (2022). Is a Catalyst Always Needed? The Case of the Knoevenagel Reaction with Malononitrile. CHEMCATCHEM, 14(18) [10.1002/cctc.202200696].

Is a Catalyst Always Needed? The Case of the Knoevenagel Reaction with Malononitrile

Campisciano V.;Giacalone F.;Gruttadauria M.
2022

Abstract

The aim of this Perspective is to start a discussion about the real usefulness of more or less sophisticated catalytic systems for the Knoevenagel reaction with malononitrile, a reaction that can take place under mild conditions without the need of a catalyst. From a sustainable viewpoint the questions are: Is it useful to increase the rate of a reaction that already occurs under mild conditions? Is it useful to spend resources and time in designing, characterizing and realizing complex catalytic systems for such reaction? Does it make sense to carry out the reaction under conditions such as to have a slower reaction rate and therefore to find a catalyst that is able to increase it?
Settore CHIM/06 - Chimica Organica
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202200696
Campisciano V., Giacalone F., Gruttadauria M. (2022). Is a Catalyst Always Needed? The Case of the Knoevenagel Reaction with Malononitrile. CHEMCATCHEM, 14(18) [10.1002/cctc.202200696].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/569367
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