(1) Background: Alpha-synuclein (α-syn) is a presynaptic neuronal protein that regulates several neuronal functions. In recent decades, the role of α-syn as a biomarker of neurodegenerative diseases has been explored, especially in synucleinopathies. However, only a few studies have assessed its role as biomarker in other neurological disorders. The aim of the study was to evaluate cerebrospinal fluid (CSF) α-syn levels in several neurological disorders; (2) Methods: We measured CSF α-syn levels by a commercial ELISA kit in 158 patients classified in the following group: controls, Alzheimer's Disease (AD), cerebrovascular diseases, inflammatory central nervous system diseases, other neurological diseases, Parkinson's Disease (PD), and peripheral neuropathy; (3) Results: Patients with PD showed the lowest and patients with AD the highest levels of CSF α-syn (1372 vs. 2912 pg/mL, respectively, p < 0.001). In AD patients, α-syn levels were significantly associated with tau proteins; (4) Conclusions: α-syn could represent a biomarker of neurodegenerative diseases.

Agnello, L., Lo Sasso, B., Vidali, M., Scazzone, C., Gambino, C.M., Piccoli, T., et al. (2022). Evaluation of Alpha-Synuclein Cerebrospinal Fluid Levels in Several Neurological Disorders. JOURNAL OF CLINICAL MEDICINE, 11(11), 1-7 [10.3390/jcm11113139].

Evaluation of Alpha-Synuclein Cerebrospinal Fluid Levels in Several Neurological Disorders

Agnello, Luisa
Primo
;
Lo Sasso, Bruna;Scazzone, Concetta;Gambino, Caterina Maria;Piccoli, Tommaso;Bivona, Giulia;Ciaccio, Anna Maria;Giglio, Rosaria Vincenza;La Bella, Vincenzo;Ciaccio, Marcello
Ultimo
2022-06

Abstract

(1) Background: Alpha-synuclein (α-syn) is a presynaptic neuronal protein that regulates several neuronal functions. In recent decades, the role of α-syn as a biomarker of neurodegenerative diseases has been explored, especially in synucleinopathies. However, only a few studies have assessed its role as biomarker in other neurological disorders. The aim of the study was to evaluate cerebrospinal fluid (CSF) α-syn levels in several neurological disorders; (2) Methods: We measured CSF α-syn levels by a commercial ELISA kit in 158 patients classified in the following group: controls, Alzheimer's Disease (AD), cerebrovascular diseases, inflammatory central nervous system diseases, other neurological diseases, Parkinson's Disease (PD), and peripheral neuropathy; (3) Results: Patients with PD showed the lowest and patients with AD the highest levels of CSF α-syn (1372 vs. 2912 pg/mL, respectively, p < 0.001). In AD patients, α-syn levels were significantly associated with tau proteins; (4) Conclusions: α-syn could represent a biomarker of neurodegenerative diseases.
Settore BIO/12 - Biochimica Clinica E Biologia Molecolare Clinica
https://doi.org/10.3390/jcm11113139
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181117/pdf/jcm-11-03139.pdf
Agnello, L., Lo Sasso, B., Vidali, M., Scazzone, C., Gambino, C.M., Piccoli, T., et al. (2022). Evaluation of Alpha-Synuclein Cerebrospinal Fluid Levels in Several Neurological Disorders. JOURNAL OF CLINICAL MEDICINE, 11(11), 1-7 [10.3390/jcm11113139].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/567473
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