There is increasing evidence that early liver transplantation (eLT), performed within standardized protocols can improve survival in severe alcoholic hepatitis (sAH). The aim of the study was to assess outcomes after eLT for sAH in four Italian LT cent- ers and to compare them with non-responders to medical therapy excluded from eLT. Patients admitted for sAH (2013–2019), according to NIAAA criteria, were in- cluded. Patients not responding to medical therapy were placed on the waiting list for eLT after a strict selection. Histological features of explanted livers were evaluated. Posttransplant survival and alcohol relapse were evaluated. Ninety-three patients with severe AH were evaluated (65.6% male, median [IQR] age: 47 [42–56] years). Forty-five of 93 patients received corticosteroids, 52 of 93 were non-responders and among these, 20 patients were waitlisted. Sixteen patients underwent LT. Overall, 6-, 12-, and 24-month survival rates were 100% significantly higher compared with non- responders to medical therapy who were denied LT (45%, 45%, and 36%; p < .001). 2/16 patients resumed alcohol intake, one at 164 days and one at 184 days. Early LT significantly improves survival in sAH non-responding to medical therapy, when a strict selection process is applied. Further studies are needed to properly assess alcohol relapse rates

Germani Giacomo, Belli Luca Saverio, Addolorato Giovanni, Merli Manuela, Mazzelli Chiara, Tarli Claudia, et al. (2022). Liver transplantation for severe alcoholic hepatitis: a multicentre Italian study. AMERICAN JOURNAL OF TRANSPLANTATION, 22(4), 1191-1200 [10.1111/ajt.16936].

Liver transplantation for severe alcoholic hepatitis: a multicentre Italian study

Craxì Lucia;
2022-04

Abstract

There is increasing evidence that early liver transplantation (eLT), performed within standardized protocols can improve survival in severe alcoholic hepatitis (sAH). The aim of the study was to assess outcomes after eLT for sAH in four Italian LT cent- ers and to compare them with non-responders to medical therapy excluded from eLT. Patients admitted for sAH (2013–2019), according to NIAAA criteria, were in- cluded. Patients not responding to medical therapy were placed on the waiting list for eLT after a strict selection. Histological features of explanted livers were evaluated. Posttransplant survival and alcohol relapse were evaluated. Ninety-three patients with severe AH were evaluated (65.6% male, median [IQR] age: 47 [42–56] years). Forty-five of 93 patients received corticosteroids, 52 of 93 were non-responders and among these, 20 patients were waitlisted. Sixteen patients underwent LT. Overall, 6-, 12-, and 24-month survival rates were 100% significantly higher compared with non- responders to medical therapy who were denied LT (45%, 45%, and 36%; p < .001). 2/16 patients resumed alcohol intake, one at 164 days and one at 184 days. Early LT significantly improves survival in sAH non-responding to medical therapy, when a strict selection process is applied. Further studies are needed to properly assess alcohol relapse rates
https://onlinelibrary.wiley.com/doi/10.1111/ajt.16936
Germani Giacomo, Belli Luca Saverio, Addolorato Giovanni, Merli Manuela, Mazzelli Chiara, Tarli Claudia, et al. (2022). Liver transplantation for severe alcoholic hepatitis: a multicentre Italian study. AMERICAN JOURNAL OF TRANSPLANTATION, 22(4), 1191-1200 [10.1111/ajt.16936].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/565203
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