We performed a study on 25 common carotid arteries (CCA) affected by atherosclerotic plaques, comparing them to 25 normal CCA. We researched the presence and localisation of atrial natriuretic factor (ANF) and oxytocin (OX) by immunohistochemistry. We found ANF abundantly expressed in plaques, mainly localising in intima and subintima layers; by contrast normal vessels were scarcely positive or negative; finally, OX resulted negative or weakly positive in both atherosclerotic and normal vessels. Our results show for the first time ANF presence in atherosclerotic plaques of CCA and are in agreement with other studies, mainly performed in vitro, that hypothesise the involvement of this molecule in the modulation of atherosclerotic inflammatory lesions and its use as anti-inflammatory agent

La Barbera, G., La Marca, G., Valentino, F., Lipari, D., Peri, G., Cappello, F., et al. (2009). Atrial natriuretic factor, but not oxytocin, is present in atherosclerotic plaques of human common carotid arteries. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, 114(2-3), 129-136.

Atrial natriuretic factor, but not oxytocin, is present in atherosclerotic plaques of human common carotid arteries

LIPARI, Diego;PERI, Giovanni;CAPPELLO, Francesco;VALENTINO, Biagio
2009-01-01

Abstract

We performed a study on 25 common carotid arteries (CCA) affected by atherosclerotic plaques, comparing them to 25 normal CCA. We researched the presence and localisation of atrial natriuretic factor (ANF) and oxytocin (OX) by immunohistochemistry. We found ANF abundantly expressed in plaques, mainly localising in intima and subintima layers; by contrast normal vessels were scarcely positive or negative; finally, OX resulted negative or weakly positive in both atherosclerotic and normal vessels. Our results show for the first time ANF presence in atherosclerotic plaques of CCA and are in agreement with other studies, mainly performed in vitro, that hypothesise the involvement of this molecule in the modulation of atherosclerotic inflammatory lesions and its use as anti-inflammatory agent
Settore BIO/16 - Anatomia Umana
La Barbera, G., La Marca, G., Valentino, F., Lipari, D., Peri, G., Cappello, F., et al. (2009). Atrial natriuretic factor, but not oxytocin, is present in atherosclerotic plaques of human common carotid arteries. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, 114(2-3), 129-136.
File in questo prodotto:
File Dimensione Formato  
La Barbera et al 2009.pdf

Solo gestori archvio

Dimensione 485.73 kB
Formato Adobe PDF
485.73 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/55690
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact