The reaction conditions for an enantiospecific synthesis of various N-aryl-oxazolidinones from N-aryl-carbamates and (R) or (S) epichlorohydrin were optimized. The N-aryl-oxazolidinones were applied to the synthesis of compounds of biological interest such as DuP 721, toloxatone and a linezolid analogue.
Moreno L.M., Marzullo P., Buscemi S., Insuasty B., Palumbo Piccionello A. (2022). Synthesis of oxazolidinones from N-aryl-carbamate and epichlorohydrin under mild conditions. ARKIVOC, 2022(2), 140-155 [10.24820/ark.5550190.p011.706].
Synthesis of oxazolidinones from N-aryl-carbamate and epichlorohydrin under mild conditions
Marzullo P.Secondo
;Buscemi S.;Palumbo Piccionello A.
Ultimo
2022-03-02
Abstract
The reaction conditions for an enantiospecific synthesis of various N-aryl-oxazolidinones from N-aryl-carbamates and (R) or (S) epichlorohydrin were optimized. The N-aryl-oxazolidinones were applied to the synthesis of compounds of biological interest such as DuP 721, toloxatone and a linezolid analogue.
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