Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.
BRUNO, M., ROSSELLI, S., MAGGIO, A.M., RACCUGLIA, R.A., BASTOW, K.F., WU C-C, et al. (2005). Cytotoxic activity of some natural and syntetic sesquiterpene lactones. PLANTA MEDICA, 71, 1176-1178 [10.1055/s-2005-873139].
Cytotoxic activity of some natural and syntetic sesquiterpene lactones
BRUNO, Maurizio;ROSSELLI, Sergio;MAGGIO, Antonella Maria;RACCUGLIA, Rosa Angela;
2005-01-01
Abstract
Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.
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