It has long been known that blood pressure (BP) is characterized by marked short-term fluctuations occurring within a 24-h period and also by long-term oscillations occurring over more prolonged periods of time. An increased short-term blood pressure variability (BPV) appears to importantly contribute to target organ damage and to the enhanced cardiovascular risk of hypertensive patients, over and above the effect of an increase in mean BP levels. Reducing 24-h mean BP is the main aim of antihypertensive therapy, but initial data are available that additional cardiovascular protection can be achieved by reducing BPV. However, to definitively prove the prognostic role of short-term BPV and the need for its control by treatment, evidence is still needed from intervention trials aimed at demonstrating that by reducing BPV through administration of antihypertensive drugs, a reduction in organ damage and in the rate of cardiovascular events can be obtained.

Mule' G., Sorce A., Vario M.G., Giambrone M., Cottone S. (2021). Should reduction of increased short-term blood pressure variability be a target of antihypertensive therapy?. THE JOURNAL OF CLINICAL HYPERTENSION, 23(6), 1162-1164 [10.1111/jch.14210].

Should reduction of increased short-term blood pressure variability be a target of antihypertensive therapy?

Mule' G.;Vario M. G.;Giambrone M.;Cottone S.
2021-06-21

Abstract

It has long been known that blood pressure (BP) is characterized by marked short-term fluctuations occurring within a 24-h period and also by long-term oscillations occurring over more prolonged periods of time. An increased short-term blood pressure variability (BPV) appears to importantly contribute to target organ damage and to the enhanced cardiovascular risk of hypertensive patients, over and above the effect of an increase in mean BP levels. Reducing 24-h mean BP is the main aim of antihypertensive therapy, but initial data are available that additional cardiovascular protection can be achieved by reducing BPV. However, to definitively prove the prognostic role of short-term BPV and the need for its control by treatment, evidence is still needed from intervention trials aimed at demonstrating that by reducing BPV through administration of antihypertensive drugs, a reduction in organ damage and in the rate of cardiovascular events can be obtained.
21-giu-2021
Mule' G., Sorce A., Vario M.G., Giambrone M., Cottone S. (2021). Should reduction of increased short-term blood pressure variability be a target of antihypertensive therapy?. THE JOURNAL OF CLINICAL HYPERTENSION, 23(6), 1162-1164 [10.1111/jch.14210].
File in questo prodotto:
File Dimensione Formato  
Should reduction of increased short-term blood pressure variability be a target of antihypertensive therapy?.pdf

accesso aperto

Tipologia: Versione Editoriale
Dimensione 160.5 kB
Formato Adobe PDF
160.5 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/548880
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact