We present a fast, one step method to obtain PVA/graphene/chlorhexidine nanofibrous membranes, with a crosslinking gradient along their cross-section. Briefly, polymeric solutions were electrospun onto a heated plate, enabling the in situ crosslinking of PVA macromolecules. Of course, the crosslinking degree of such structures was found to decrease upon the distance from the plate during deposition. The outcomes reveal the crucial role of graphene, capable of promoting heat transfer throughout the entire structure, thus leading to 70-80% crosslinking degrees and preventing delamination issues. Such membranes were compared to untreated and oven thermally treated ones, and a robust relationship between processing, structure and properties was outlined, with a special focus on the release behaviour of such materials, which proved to be tuneable from instantaneous/burst to sustained release (up to 500 hours) by adjusting formulation and preparation technique.

Emmanuel Fortunato Gulino, Maria Clara Citarrella, Andrea Maio, Roberto Scaffaro (2022). An innovative route to prepare in situ graded crosslinked PVA graphene electrospun mats for drug release. COMPOSITES. PART A: APPLIED SCIENCE AND MANUFACTURING, 155 [10.1016/j.compositesa.2022.106827].

An innovative route to prepare in situ graded crosslinked PVA graphene electrospun mats for drug release

Emmanuel Fortunato Gulino
Primo
;
Maria Clara Citarrella
Secondo
;
Andrea Maio
Penultimo
;
Roberto Scaffaro
Ultimo
2022-01-01

Abstract

We present a fast, one step method to obtain PVA/graphene/chlorhexidine nanofibrous membranes, with a crosslinking gradient along their cross-section. Briefly, polymeric solutions were electrospun onto a heated plate, enabling the in situ crosslinking of PVA macromolecules. Of course, the crosslinking degree of such structures was found to decrease upon the distance from the plate during deposition. The outcomes reveal the crucial role of graphene, capable of promoting heat transfer throughout the entire structure, thus leading to 70-80% crosslinking degrees and preventing delamination issues. Such membranes were compared to untreated and oven thermally treated ones, and a robust relationship between processing, structure and properties was outlined, with a special focus on the release behaviour of such materials, which proved to be tuneable from instantaneous/burst to sustained release (up to 500 hours) by adjusting formulation and preparation technique.
gen-2022
Settore ING-IND/22 - Scienza E Tecnologia Dei Materiali
Emmanuel Fortunato Gulino, Maria Clara Citarrella, Andrea Maio, Roberto Scaffaro (2022). An innovative route to prepare in situ graded crosslinked PVA graphene electrospun mats for drug release. COMPOSITES. PART A: APPLIED SCIENCE AND MANUFACTURING, 155 [10.1016/j.compositesa.2022.106827].
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1359835X22000239-main-compresso.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 959.26 kB
Formato Adobe PDF
959.26 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
pre-print.pdf

accesso aperto

Descrizione: pre-print
Tipologia: Pre-print
Dimensione 4.34 MB
Formato Adobe PDF
4.34 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/547345
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 20
social impact