Aim: Resistive index of ophthalmic artery (RI-OA) is associated with atherosclerotic diseases. The aim of this study was to evaluate the association of RI-OA and hypertension-related vascular and kidney damage. Materials and methods: Two-hundred and eighty hypertensive patients underwent evaluation of RI-OA, carotid atherosclerosis and level of 24 h albuminuria. Results: Albuminuria and carotid atherosclerosis were positively associated with RI-OA independently of other cardiovascular risk factors. Receiver-operating characteristic curve analysis allowed us to calculate a cut-off value of RI-OA >0.625, which would be suspicious about the existence of atherosclerotic disease. Conclusion: The ophthalmic vascular circulation allows to study connections between macro- and microcirculation in vivo. RI-OA could be a useful marker for a better stratification of the risk of developing kidney and cardiovascular disease.

Mattina, A., Geraci, G., Zammuto, M., Maida, C., Giammanco, A., Nardi, E., et al. (2021). Resistive index of ophthalmic artery as an imaging biomarker of hypertension-related vascular and kidney damage. BIOMARKERS IN MEDICINE, 15(13), 1155-1166 [10.2217/bmm-2020-0829].

Resistive index of ophthalmic artery as an imaging biomarker of hypertension-related vascular and kidney damage

Mattina, Alessandro
;
Geraci, Giulio;Zammuto, Marta;Maida, Carlo;Giammanco, Antonina;Nardi, Emilio;Tuzzolino, Fabio;Averna, Maurizio;Cottone, Santina;Mulè, Giuseppe
2021-08-16

Abstract

Aim: Resistive index of ophthalmic artery (RI-OA) is associated with atherosclerotic diseases. The aim of this study was to evaluate the association of RI-OA and hypertension-related vascular and kidney damage. Materials and methods: Two-hundred and eighty hypertensive patients underwent evaluation of RI-OA, carotid atherosclerosis and level of 24 h albuminuria. Results: Albuminuria and carotid atherosclerosis were positively associated with RI-OA independently of other cardiovascular risk factors. Receiver-operating characteristic curve analysis allowed us to calculate a cut-off value of RI-OA >0.625, which would be suspicious about the existence of atherosclerotic disease. Conclusion: The ophthalmic vascular circulation allows to study connections between macro- and microcirculation in vivo. RI-OA could be a useful marker for a better stratification of the risk of developing kidney and cardiovascular disease.
16-ago-2021
Settore MED/09 - Medicina Interna
Settore MED/14 - Nefrologia
Mattina, A., Geraci, G., Zammuto, M., Maida, C., Giammanco, A., Nardi, E., et al. (2021). Resistive index of ophthalmic artery as an imaging biomarker of hypertension-related vascular and kidney damage. BIOMARKERS IN MEDICINE, 15(13), 1155-1166 [10.2217/bmm-2020-0829].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/540835
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