Helianthemum lippii is a perennial shrubby plant growing in the sandy environments of Italy, Mediterranean countries of North Africa and Middle East. H. lippii is used in traditional medicine but there are very few reports referring to the phytochemical characterization, the ethnopharmacology, and the biological activity of H. lippii. The goal of this study was todetermine the phytochemical composition of different H. lippii extracts, cold (CME) and hot (HME) methanol, cold (CPEE) and hot (HPEE) petroleum ether, as well as to evaluate their anticancer and antimicrobial activities and biofilm formation reduction. Fifty-fours phytocompounds have been determined by HPLC-UV-ESI-QTOF-MS analysis. All the four extracts reduced the viability of human MDA-MB231 and HCT116 cells, being cold and hot methanol extracts the most effective. The antimicrobial activity against S. aureus, P. aeruginosa, E. faecalis, E. coli, C. albicans was also evaluated. Data showed the greater susceptibility of S. aureus to hot methanolic extract. Concerning antifungal activity, C. albicans resulted more susceptible to petroleum ether. Moreover, some of the samples exhibited a good antibiofilm activity both on immature and on mature biofilms. The four extracts showed interesting antimicrobial and cytotoxic activities and can be considered good candidates for new therapeutic applications

Fabiana Plescia, Fabio Venturella, Antonella D’Anneo, Valentina Catania, Maria Letizia Gargano, Giulia Polito, et al. (2022). Phytochemical-rich extracts of Helianthemum lippii possess antimicrobial, anticancer, and antibiofilm activities. PLANT BIOSYSTEMS, 156(6), 1314-1324 [10.1080/11263504.2022.2048274].

Phytochemical-rich extracts of Helianthemum lippii possess antimicrobial, anticancer, and antibiofilm activities

Fabiana Plescia;Fabio Venturella;Antonella D’Anneo;Valentina Catania;Giulia Polito;Domenico Schillaci;Antonio Palumbo Piccionello;Marianna Lauricella;Giuseppe Venturella;Demetrio Raffa
2022-01-01

Abstract

Helianthemum lippii is a perennial shrubby plant growing in the sandy environments of Italy, Mediterranean countries of North Africa and Middle East. H. lippii is used in traditional medicine but there are very few reports referring to the phytochemical characterization, the ethnopharmacology, and the biological activity of H. lippii. The goal of this study was todetermine the phytochemical composition of different H. lippii extracts, cold (CME) and hot (HME) methanol, cold (CPEE) and hot (HPEE) petroleum ether, as well as to evaluate their anticancer and antimicrobial activities and biofilm formation reduction. Fifty-fours phytocompounds have been determined by HPLC-UV-ESI-QTOF-MS analysis. All the four extracts reduced the viability of human MDA-MB231 and HCT116 cells, being cold and hot methanol extracts the most effective. The antimicrobial activity against S. aureus, P. aeruginosa, E. faecalis, E. coli, C. albicans was also evaluated. Data showed the greater susceptibility of S. aureus to hot methanolic extract. Concerning antifungal activity, C. albicans resulted more susceptible to petroleum ether. Moreover, some of the samples exhibited a good antibiofilm activity both on immature and on mature biofilms. The four extracts showed interesting antimicrobial and cytotoxic activities and can be considered good candidates for new therapeutic applications
2022
Settore CHIM/08 - Chimica Farmaceutica
Settore BIO/10 - Biochimica
Settore BIO/19 - Microbiologia Generale
Settore BIO/14 - Farmacologia
Settore BIO/02 - Botanica Sistematica
Fabiana Plescia, Fabio Venturella, Antonella D’Anneo, Valentina Catania, Maria Letizia Gargano, Giulia Polito, et al. (2022). Phytochemical-rich extracts of Helianthemum lippii possess antimicrobial, anticancer, and antibiofilm activities. PLANT BIOSYSTEMS, 156(6), 1314-1324 [10.1080/11263504.2022.2048274].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/540447
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