2′-5′-Oligoadenylate synthetase 1 (OAS1) is one of the key enzymes driving the innate immune system response to SARS-CoV-2 infection whose activity has been related to COVID-19 severity. OAS1 is a sensor of endogenous RNA that triggers the 2′-5′-oligoadenylate/RNase L pathway. Upon SARS-CoV-2 infection, OAS1 is responsible for the recognition of viral RNA and has been shown to possess a particularly high sensitivity for the 5′-untranslated (5′-UTR) RNA region, which is organized in a double-strand stem loop motif (SL1). Here we report the structure of the SL1/OAS1 complex also rationalizing the high affinity for OAS1.

Bignon E., Miclot T., Terenzi A., Barone G., Monari A. (2022). Structure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1. CHEMICAL COMMUNICATIONS, 58(13), 2176-2179 [10.1039/d1cc07006a].

Structure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1

Miclot T.
Membro del Collaboration Group
;
Terenzi A.
Membro del Collaboration Group
;
Barone G.
Membro del Collaboration Group
;
2022-01-01

Abstract

2′-5′-Oligoadenylate synthetase 1 (OAS1) is one of the key enzymes driving the innate immune system response to SARS-CoV-2 infection whose activity has been related to COVID-19 severity. OAS1 is a sensor of endogenous RNA that triggers the 2′-5′-oligoadenylate/RNase L pathway. Upon SARS-CoV-2 infection, OAS1 is responsible for the recognition of viral RNA and has been shown to possess a particularly high sensitivity for the 5′-untranslated (5′-UTR) RNA region, which is organized in a double-strand stem loop motif (SL1). Here we report the structure of the SL1/OAS1 complex also rationalizing the high affinity for OAS1.
2022
Settore CHIM/03 - Chimica Generale E Inorganica
Bignon E., Miclot T., Terenzi A., Barone G., Monari A. (2022). Structure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1. CHEMICAL COMMUNICATIONS, 58(13), 2176-2179 [10.1039/d1cc07006a].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/537195
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