Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to Imatinib. Imanitib is a drug used to treat certain types of cancer that in many statistical studies has been reported to have a significant clinical effect on chronic myeloid leukemia (CML) in chronic phase as well as in blast crisis. For central module in a GGM we intend a module containing genes that are defined differently expressed.

Augugliaro, L., Mineo, A. (2009). Identifying modularity structure of a genetic network in gene expression profile data. STATISTICA, 69, 187-200.

Identifying modularity structure of a genetic network in gene expression profile data

AUGUGLIARO, Luigi;MINEO, Angelo
2009-01-01

Abstract

Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to Imatinib. Imanitib is a drug used to treat certain types of cancer that in many statistical studies has been reported to have a significant clinical effect on chronic myeloid leukemia (CML) in chronic phase as well as in blast crisis. For central module in a GGM we intend a module containing genes that are defined differently expressed.
2009
Augugliaro, L., Mineo, A. (2009). Identifying modularity structure of a genetic network in gene expression profile data. STATISTICA, 69, 187-200.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/53717
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