Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dysregulates the immune system by lymphopenia of B cells, monocytes, eosinophils, basophils, and cytotoxic cells such as CD8, γδ T cells, and natural killer (NK) cells. Despite many studies being conducted to better understand the effects of SARS-CoV-2 on the immune system, many mechanisms still remain unclear, hindering the development of novel therapeutic approaches and strategies to improve the host’s immune defense. This mini-review summarizes the findings on the role of γδ T cells in coronavirus disease 2019 (COVID-19), providing an overview of the excellent anti-viral therapeutic potential of γδ T cells, that had not yet been exploited in depth.

Lo Presti E., Dieli F., Meraviglia S. (2021). Lymphopenia in covid-19: γδ t cells-based therapeutic opportunities. VACCINES, 9(6), 1-9 [10.3390/vaccines9060562].

Lymphopenia in covid-19: γδ t cells-based therapeutic opportunities

Lo Presti E.
;
Dieli F.;Meraviglia S.
2021-05-28

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dysregulates the immune system by lymphopenia of B cells, monocytes, eosinophils, basophils, and cytotoxic cells such as CD8, γδ T cells, and natural killer (NK) cells. Despite many studies being conducted to better understand the effects of SARS-CoV-2 on the immune system, many mechanisms still remain unclear, hindering the development of novel therapeutic approaches and strategies to improve the host’s immune defense. This mini-review summarizes the findings on the role of γδ T cells in coronavirus disease 2019 (COVID-19), providing an overview of the excellent anti-viral therapeutic potential of γδ T cells, that had not yet been exploited in depth.
28-mag-2021
Lo Presti E., Dieli F., Meraviglia S. (2021). Lymphopenia in covid-19: γδ t cells-based therapeutic opportunities. VACCINES, 9(6), 1-9 [10.3390/vaccines9060562].
File in questo prodotto:
File Dimensione Formato  
Lo Presti vaccines 2021.pdf

accesso aperto

Tipologia: Versione Editoriale
Dimensione 509.99 kB
Formato Adobe PDF
509.99 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/528070
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 5
social impact