In the last decade, an increasing number of studies have demonstrated that non-coding RNA (ncRNAs) cooperate in the gene regulatory networks with other biomolecules, including coding RNAs, DNAs and proteins. Among them, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are involved in transcriptional and translation regulation at different levels. Intriguingly, ncRNAs can be packed in vesicles, released in the extracellular space, and finally internalized by receiving cells, thus affecting gene expression also at distance. This review focuses on the mechanisms through which the ncRNAs can be selectively packaged into extracellular vesicles (EVs).

Corrado C., Barreca M.M., Zichittella C., Alessandro R., & Conigliaro A. (2021). Molecular mediators of RNA loading into extracellular vesicles. CELLS, 10(12) [10.3390/cells10123355].

Molecular mediators of RNA loading into extracellular vesicles

Corrado C.;Barreca M. M.;Zichittella C.;Alessandro R.;Conigliaro A.
2021-11-30

Abstract

In the last decade, an increasing number of studies have demonstrated that non-coding RNA (ncRNAs) cooperate in the gene regulatory networks with other biomolecules, including coding RNAs, DNAs and proteins. Among them, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are involved in transcriptional and translation regulation at different levels. Intriguingly, ncRNAs can be packed in vesicles, released in the extracellular space, and finally internalized by receiving cells, thus affecting gene expression also at distance. This review focuses on the mechanisms through which the ncRNAs can be selectively packaged into extracellular vesicles (EVs).
Settore BIO/13 - Biologia Applicata
Corrado C., Barreca M.M., Zichittella C., Alessandro R., & Conigliaro A. (2021). Molecular mediators of RNA loading into extracellular vesicles. CELLS, 10(12) [10.3390/cells10123355].
File in questo prodotto:
File Dimensione Formato  
cells-10-03355.pdf

accesso aperto

Descrizione: Articolo
Tipologia: Versione Editoriale
Dimensione 1.69 MB
Formato Adobe PDF
1.69 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/526794
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? ND
social impact