Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
Di Franco, S., Stassi, G. (2021). Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype. MOLECULAR & CELLULAR ONCOLOGY [10.1080/23723556.2021.1986343].
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
Di Franco, Simone;Stassi, Giorgio
2021-10-18
Abstract
Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
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