SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1–6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1–2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2–3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9–3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3–6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Li, E., Emanuele Cammarata, S.C. (2022). SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. ANAESTHESIA, 77(1), 28-39 [10.1111/anae.15563].

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Emanuele Cammarata
Membro del Collaboration Group
;
Sofia Campanella
Membro del Collaboration Group
;
Daniela Canzonieri
Membro del Collaboration Group
;
Adriana Cordova
Membro del Collaboration Group
;
Federico De Michele
Membro del Collaboration Group
;
Ettore Dinoto
Membro del Collaboration Group
;
Mara Franza
Membro del Collaboration Group
;
Leo Licari
Membro del Collaboration Group
;
Daniele Matta
Membro del Collaboration Group
;
Domenico Mirabella
Membro del Collaboration Group
;
Felice Pecoraro
Membro del Collaboration Group
;
Roberto Pirrello
Membro del Collaboration Group
;
Fernando Rosatti
Membro del Collaboration Group
;
Giuseppe Salamone
Membro del Collaboration Group
;
Francesca Toia
Membro del Collaboration Group
;
Massimiliano Tripoli
Membro del Collaboration Group
;
Vito Chiantera
Membro del Collaboration Group
;
Leo Licari
Membro del Collaboration Group
2022-01-01

Abstract

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1–6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1–2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2–3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9–3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3–6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.
gen-2022
Li, E., Emanuele Cammarata, S.C. (2022). SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. ANAESTHESIA, 77(1), 28-39 [10.1111/anae.15563].
File in questo prodotto:
File Dimensione Formato  
128_2021_COVIDColl_venous embolism.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 958.98 kB
Formato Adobe PDF
958.98 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/520930
Citazioni
  • ???jsp.display-item.citation.pmc??? 58
  • Scopus 87
  • ???jsp.display-item.citation.isi??? 73
social impact