Salvinorin A (1), a neoclerodane diterpene from the hallucinogenic mint Salvia divinorum, is the only known non-nitrogenous and specific k-opioid agonist. Several structural congeners of 1 isolated from Salvia splendens (2–8) together with a series of semisynthetic derivatives (9–24), some of which possess a pyrazoline structural moiety (9, 19–22), have been tested for affinity at human m, d, and k opioid receptors. None of these compounds showed high affinity binding to these receptors. However, 10 showed modest affinity for k receptors suggesting that other natural neoclerodanes from different Salvia species may possess opioid affinity.
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/10447/51657
Data di pubblicazione: | 2008 |
Titolo: | Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity |
Autori: | Fontana, G.; Savona, G.; Rodriguez, B.; Dersch, C.; Rothman, R.; Prisinzano, T. |
Autori: | |
Tipologia: | Articolo su rivista |
Citazione: | Fontana, G., Savona, G., Rodriguez, B., Dersch, C., Rothman, R., & Prisinzano, T. (2008). Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity. TETRAHEDRON, 64, 10041-10048. |
Tipo: | Articolo in rivista |
Digital Object Identifier (DOI): | 10.1016/j.tet.2008.08.043 |
Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
2008Tet10041.pdf | articolo full text | N/A | Administrator Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.