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EnglishSalvinorin A (1), a neoclerodane diterpene from the hallucinogenic mint Salvia divinorum, is the only known non-nitrogenous and specific k-opioid agonist. Several structural congeners of 1 isolated from Salvia splendens (2–8) together with a series of semisynthetic derivatives (9–24), some of which possess a pyrazoline structural moiety (9, 19–22), have been tested for affinity at human m, d, and k opioid receptors. None of these compounds showed high affinity binding to these receptors. However, 10 showed modest affinity for k receptors suggesting that other natural neoclerodanes from different Salvia species may possess opioid affinity.
Fontana, G., Savona, G., Rodriguez, B., Dersch, C., Rothman, R., & Prisinzano, T. (2008). Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity. TETRAHEDRON, 64, 10041-10048 [10.1016/j.tet.2008.08.043].
| Data di pubblicazione: | 2008 | |
| Titolo: | Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity | |
| Autori: | ||
| Citazione: | Fontana, G., Savona, G., Rodriguez, B., Dersch, C., Rothman, R., & Prisinzano, T. (2008). Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity. TETRAHEDRON, 64, 10041-10048 [10.1016/j.tet.2008.08.043]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tet.2008.08.043 | |
| Abstract: | Salvinorin A (1), a neoclerodane diterpene from the hallucinogenic mint Salvia divinorum, is the only known non-nitrogenous and specific k-opioid agonist. Several structural congeners of 1 isolated from Salvia splendens (2–8) together with a series of semisynthetic derivatives (9–24), some of which possess a pyrazoline structural moiety (9, 19–22), have been tested for affinity at human m, d, and k opioid receptors. None of these compounds showed high affinity binding to these receptors. However, 10 showed modest affinity for k receptors suggesting that other natural neoclerodanes from different Salvia species may possess opioid affinity. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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