Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in Vitiligo patients. Catalase is a well known oxidative stress regulator that could play an important role in the pathogenesis of Vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with Vitiligo susceptibility in Sicilian population.
Caputo, V., Niceta, M., Fiorella, S., La Vecchia, M., Bastonini, E., Bongiorno, M.R., et al. (2018). Vitiligo susceptibility and catalase gene (CAT) polymorphisms in sicilian population. GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, 153(5), 619-623 [10.23736/S0392-0488.17.05488-8].
Vitiligo susceptibility and catalase gene (CAT) polymorphisms in sicilian population
Caputo, Valentina;Niceta, Marcello;Fiorella, Santi;LA VECCHIA, Marco;Bongiorno, Maria R;Pistone, Giuseppe
2018-01-01
Abstract
Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in Vitiligo patients. Catalase is a well known oxidative stress regulator that could play an important role in the pathogenesis of Vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with Vitiligo susceptibility in Sicilian population.
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