Statin therapy has been the cornerstone for the reduction of cholesterol and circulating low-density lipoprotein (LDL) in patients with cardiovascular diseases. However, statin monotherapy has disadvantages attributable to myopathies and to the insufficient cholesterol reduction observed in some patients. There is a need for new well-tolerated therapies for lowering LDL. This review will focus on bempedoic acid in combination with traditional statin therapy or other lipid-lowering agents and its emerging role in LDL-C lowering. Bempedoic acid is also a viable alternative for reducing LDL cholesterol in the treatment of some patients suffering from heterozygous familial hypercholesterolemia.

Schimmenti C., Sucato V., Manzone E., Cancellieri G., Mortillaro F., Novo G., et al. (2021). Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia. CORONARY ARTERY DISEASE, 32(4), 340-344 [10.1097/MCA.0000000000000976].

Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia

Sucato V.
Conceptualization
;
Cancellieri G.;Mortillaro F.;Novo G.;Galassi A. R.;Venturella F.
2021

Abstract

Statin therapy has been the cornerstone for the reduction of cholesterol and circulating low-density lipoprotein (LDL) in patients with cardiovascular diseases. However, statin monotherapy has disadvantages attributable to myopathies and to the insufficient cholesterol reduction observed in some patients. There is a need for new well-tolerated therapies for lowering LDL. This review will focus on bempedoic acid in combination with traditional statin therapy or other lipid-lowering agents and its emerging role in LDL-C lowering. Bempedoic acid is also a viable alternative for reducing LDL cholesterol in the treatment of some patients suffering from heterozygous familial hypercholesterolemia.
Schimmenti C., Sucato V., Manzone E., Cancellieri G., Mortillaro F., Novo G., et al. (2021). Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia. CORONARY ARTERY DISEASE, 32(4), 340-344 [10.1097/MCA.0000000000000976].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/513660
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