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EnglishThe exposure of cancer cells to cadmium and its compounds is often associated with the development of more malignant phenotypes, thereby contributing to the acceleration of tumor progression. It is known that cadmium is a transcriptional regulator that induces molecular reprogramming, and therefore the study of differentially expressed genes has enabled the identification and classification of molecular signatures inherent in human neoplastic cells upon cadmium exposure as useful biomarkers that are potentially transferable to clinical research. This review recapitulates selected studies that report the detection of cadmium-associated signatures in breast, gastric, colon, liver, lung, and nasopharyngeal tumor cell models, as specifically demonstrated by individual gene or whole genome expression profiling. Where available, the molecular, biochemical, and/or physiological aspects associated with the targeted gene activation or silencing in the discussed cell models are also outlined.
Luparello, C. (2021). Cadmium-Associated Molecular Signatures in Cancer Cell Models [10.3390/cancers13112823].
| Data di pubblicazione: | 2021 | |
| Titolo: | Cadmium-Associated Molecular Signatures in Cancer Cell Models | |
| Autori: | LUPARELLO, Claudio (Corresponding) | |
| Citazione: | Luparello, C. (2021). Cadmium-Associated Molecular Signatures in Cancer Cell Models [10.3390/cancers13112823]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/cancers13112823 | |
| Abstract: | The exposure of cancer cells to cadmium and its compounds is often associated with the development of more malignant phenotypes, thereby contributing to the acceleration of tumor progression. It is known that cadmium is a transcriptional regulator that induces molecular reprogramming, and therefore the study of differentially expressed genes has enabled the identification and classification of molecular signatures inherent in human neoplastic cells upon cadmium exposure as useful biomarkers that are potentially transferable to clinical research. This review recapitulates selected studies that report the detection of cadmium-associated signatures in breast, gastric, colon, liver, lung, and nasopharyngeal tumor cell models, as specifically demonstrated by individual gene or whole genome expression profiling. Where available, the molecular, biochemical, and/or physiological aspects associated with the targeted gene activation or silencing in the discussed cell models are also outlined. | |
| Settore Scientifico Disciplinare: | Settore BIO/06 - Anatomia Comparata E Citologia | |
| Appare nelle tipologie: | 1.09 Review essay (rassegna critica) |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| cancers-13-02823.pdf | Articolo | Versione Editoriale | Open Access Visualizza/Apri |
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